It is indisputable that issues surrounding the availability and purity of water, and its intimate connection to energy will be major global technical matters for society over the next several decades. The premise of this initiative is that a cooperative combination of the innovative technical resources in molecular and nanoscale science and engineering of Ben-Gurion University (BGU) in Israel with the University of Chicago (UChicago), the Argonne National Laboratory (ANL) and others in the greater Chicago area will create new, scalable tools and processes for water production, purification, preservation and re-use deployable in many regions of the globe. The joint effort is focusing on basic scientific studies of physical, chemical and biological manifestations of important and unique aspects of water and aqueous media and the sebsequent development of impactful applications of these scientific discoveries. In addition to fund close collaboration among the research scientists on an ongoing basis, the University of Chicago also provides dedicated collaboratory space in the newly opened Chicago Innovation Exchange for visiting BGU researchers to sustain this long distance interaction.